Postdoctoral Research Fellow in Onco-Hematology and Multi-omics Analyses

The Institut Paoli-Calmettes (IPC) and the Cancer Research Center Marseille (CRCM) is seeking a highly motivated and talented Postdoctoral Research Fellow to join a collaborative research project focused on multi- omic characterization of relapsed and resistant Acute Myeloid Leukemia (rrAML) for advanced biomarker and therapeutic development.

Research Environment

The IPC/CRCM is a leading Comprehensive Cancer Research Center in Marseille France, with a world-class clinical hematology service and housing over 20 teams dedicated to various aspects of cancer research. This position is located within the OHIO (Immuno-onco and Onco-Hemato) department, providing a vibrant and cutting-edge environment for translational research.

The Project

This position is available in the research group of S. Garciaz, MD, Ph.D. (Head of the Early Trial Unit), in close collaboration with the Leuko-Stromal Interactions team lead by M. Aurrand-Lions, the IPC drug development unit co-lead by T. Miller, the Marseille Proteomics Platform (MAP) and Bioinformatics core facilities. 
The successful candidate will lead a project focused on mapping the combined transcriptome and surface proteome of rrAML with respect to key driver mutations and acquired drug resistance. 
The project will specifically consist of: single cell transcriptomic sample creation, data acquisition, and analysis, cell surface protein labeling method development, and proteomic analyses (in collaboration with the MAP). 
Experiments will be carried out using AML patient cells and xenograft models.

Responsibilities

The Postdoctoral Fellow will:

• Design and execute experiments using state-of-the-art single-cell genomic and transcriptomic approaches (e.g., 10X Genomics and/or Tapestri) and proteomic techniques.
• Process and analyze complex biological data, working in close collaboration with the proteomic and bioinformatics core facilities.
• Work with primary human AML patient cells and relevant ex vivo models.
• Present research findings at lab meetings, institutional seminars, and international conferences.
• Prepare manuscripts for publication in high-impact peer-reviewed journals.

Qualifications and Experience 
Essential

• Hold a Ph.D. degree in Biological Sciences (or equivalent) at the start of the contract.
• A strong background in Immunology or Onco-Hematology is necessary. All relevant profiles will be considered, but experience in these fields is highly valued.
• Proficiency in English (written and spoken) is required.

Desired/Highly Appreciated

• Prior experience with single-cell RNA sequencing methodologies.
• Hands-on experience with advanced laboratory techniques, including cytometry and biochemistry.
• Computational skills in data analysis, particularly using R Studio or Seurat for single-cell data.

Contract Details and Career Development

• Initial Funding: 18 months CDD.
• Start Date: Dec 2025

How to Apply

Interested candidates should submit the following documents as a single PDF to Dr. S. Garciaz and T. Miller at Thomas.miller@inserm.fr with the subject “Postdoc_Onco-Hematology”:

1. A detailed Curriculum Vitae (CV).
2. A cover letter outlining research interests, relevant experience, and motivation for the position.
3. Contact information (Name, affiliation, email) for at least two academic references.

Application Deadline: 15 Nov 2025